A novel green and efficient one-pot multicomponent synthesis of dihydropyridine derivatives in good to excellent yield were reported. In presence of CAN catalyst, different 1,3-dione and same starting material as 5-bromothiophene-2-carboxaldehyde and ammonium acetate were used under solvent and heat free (at room temperature) condition for the Hantzsch pyridine synthesis within short period of time. All compounds were evaluated for their in vitro antibacterial and antifungal activity and interestigly we found that 5b to 5f shows excellent activity than Ampicilin, whereas only 5e compound shows excellent antifungal activity against C.albicans compared to graseofulvin. The cyto-toxicity of all compounds has been assessed against Breast tumor cell lines (BT-549) but no activity was found. The X- ray structure of one such compound 5a viewing colourless block crystal was corresponded accurately to a primitive monoclinic cell.
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